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The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 190-200 doi: 10.1007/s11684-014-0323-5

Abstract:

Over the past few years, several new achievements have been made from stem cell studies, many of whichMoreover, some stem cell-based products have been approved for marketing by different national regulatoryevaluate quality, safety and efficacy of stem cell products, and for building up the appropriate regulatorycell regulatory sciences with a goal of promoting the steadfast growth of the well-regulated stem celltherapies abreast of evolvement of stem cell sciences and technologies.

Keywords： stem cell-based medicinal products (SCMPs)     stem cell therapy (SCT)     safety     effectiveness     standards     guidelines    

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MAS-based production scheduling system for manufacturing cell-based workshop

CHU Hong-yan, CAO Quan-jun, FEI Ren-yuan

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 4,   Pages 375-380 doi: 10.1007/s11465-006-0043-x

Abstract: In this paper, the manufacturing cell-based workshop is described and its scheduling system structureis established based on MAS (multi-agent system) technology.The CORBA-based architecture of the communication is designed and some interfaces for the communication

Keywords： negotiation     selection     multi-agent     communication     abnormal    

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Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 440-450 doi: tzg@ustc.edu.cn

Abstract: Various cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK cellHowever, considering the safety, activities, and reliability of the cell products, researchers must developIn this review, the challenges on NK cell-based therapeutic approaches and clinical outcomes are discussed

Keywords： natural killer cells     immunotherapy     adoptive transfer     genetic modification     immune checkpoint inhibitor    

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Static analysis of corrugated panels using homogenization models and a cell-based smoothed mindlin plate

Nhan NGUYEN-MINH, Nha TRAN-VAN, Thang BUI-XUAN, Trung NGUYEN-THOI

Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 2,   Pages 251-272 doi: 10.1007/s11709-017-0456-0

Abstract: In addition, in the recent trend of development of smoothed finite element methods, the cell-based smoothedthree-node Mindlin plate element (CS-MIN3) based on the first-order shear deformation theory (FSDT)

Keywords： homogenization     corrugated panel     asymptotic analysis     smoothed finite element method (S-FEM)     cell-based    

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An extended cell-based smoothed discrete shear gap method (XCS-FEM-DSG3) for free vibration analysis

M. H. NGUYEN-THOI,L. Le-ANH,V. Ho-HUU,H. Dang-TRUNG,T. NGUYEN-THOI

Frontiers of Structural and Civil Engineering 2015, Volume 9, Issue 4,   Pages 341-358 doi: 10.1007/s11709-015-0302-1

Abstract: A cell-based smoothed discrete shear gap method (CS-FEM-DSG3) was recently proposed and proven to beThe method improves significantly the accuracy of the solution due to softening effect of the cell-basedsingular enrichment functions of the extended finite element method (XFEM) to give a so-called extended cell-based

Keywords： cracked Reissner-Mindlin shell     free vibration analysis     cell-based smoothed discrete shear gap method(CS-FEM-DSG3)     extended cell-based smoothed discrete shear gap method (XCS-FEM-DSG3)     smoothed finite element    

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The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 348-355 doi: 10.1007/s11684-011-0150-x

Abstract: Research into the biological properties and clinical potential of stem cells has spurred strong publicof demonstrated safety and efficacy have been developed with the exception of uses of hematopoietic stembasis notwithstanding, hundreds of companies and private clinics around the world now sell putative stemcell treatments for an enormously broad range of medical and quality-of-life conditions.In this review, I provide an overview of the global industry in pseudomedical stem cell treatments, with

Keywords： stem cell tourism     medical ethics     stem cell policy and regulation     alternative medicine    

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Therapeutic potential of stem cell in liver regeneration

Jinzheng LI, Min LI, Bolin NIU, Jianping GONG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 26-32 doi: 10.1007/s11684-011-0107-0

Abstract: Stem cell therapy, with the ability for self-renewal and potential for multilineage differentiation,cells derived from multipotent stem cells leads to donor cell-mediated repopulation of the liver andHowever, a registered clinical application based on stem cell technology will take at least an additional5 to 10 years because of some limitations; e.g. the lack of suitable cell sources and risk of teratomaThis review summarizes the general understanding of the therapeutic potentials of stem cells in liver

Keywords： stem cell     liver disease     regenerative medicine    

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Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 40-44 doi: 10.1007/s11684-011-0108-z

Abstract:

Adult stem cells are responsible for homeostasis and repair of many tissues.Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, whichMany regulatory factors are involved in the stem cell-based repair process, including stem cell nichesHere we briefly review the role of stem cell niches and endogenous electric fields in tissue repair,and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.

Keywords： stem cell     stem cell niche     electric field     tissue repair    

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Transcriptomics and proteomics in stem cell research

Hai Wang,Qian Zhang,Xiangdong Fang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11684-014-0336-0

Abstract:

Stem cells are capable of self-renewal and differentiation, and the processes regulating these eventsIn particular, the molecular mechanisms of the self-renewal, proliferation, and differentiation of stemcell biology.and proteomic characterization of the different stem cell processes.cell biology and promote the clinical applications of stem cells.

Keywords： embryonic stem cells     transcriptomics     proteomics    

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Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Xiaodong Mo, Xiaojun Huang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 306-315 doi: 10.1007/s11684-013-0279-x

Abstract:

Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options forSeveral protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide

Keywords： partially matched related donor     hematopoietic stem cell transplantation     allogeneic    

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Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 227-239 doi: 10.1007/s11684-021-0896-8

Abstract: Chronic stress impairs radial neural stem cell (rNSC) differentiation and adult hippocampal neurogenesis

Keywords： cannabidiol     depression     radial neural stem cells     neurogenesis    

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In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 239-247 doi: 10.1007/s11684-011-0123-0

Abstract: imaging is crucial for developmental biology and can further help to follow cell development/differentiationhas facilitated tracing of the developmental dynamics of a specific organ, tissue, or even a single cellhematopoiesis due to its transparent embryo at early stage; moreover, different zebrafish hematopoietic stem

Keywords： hematopoietic stem cell     hematopoiesis     in vivo imaging     transgenics     zebrafish    

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Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract: mutations provides the first proof-of-principle investigation on the identification of preleukemic stemAlthough DNMT3A mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing

Keywords： preleukemic stem cell     acute myeloid leukemia     relapse     DNMT3A    

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Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 356-371 doi: 10.1007/s11684-011-0159-1

Abstract: Virus-based vectors are widely used in hematopoietic stem cell (HSC) gene therapy, and have the abilityreview will summarize current information on the mechanisms of insertional mutagenesis in hematopoietic stem

Keywords： gene therapy     hematopoietic stem cells     insertional mutagenesis     genotoxicity     induced pluripotent stem cell    

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The stem cell and tissue engineering research in Chinese ophthalmology

GE Jian, LIU Jingbo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 6-10 doi: 10.1007/s11684-007-0002-x

Abstract: Much has been considerably developed recently in the ophthalmic research of stem cell (SC) and tissue

Keywords： available     observable     neuroregeneration     protection     function reconstruction    

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Title Author Date Type Operation

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Journal Article

MAS-based production scheduling system for manufacturing cell-based workshop

CHU Hong-yan, CAO Quan-jun, FEI Ren-yuan

Journal Article

Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Journal Article

Static analysis of corrugated panels using homogenization models and a cell-based smoothed mindlin plate

Nhan NGUYEN-MINH, Nha TRAN-VAN, Thang BUI-XUAN, Trung NGUYEN-THOI

Journal Article

An extended cell-based smoothed discrete shear gap method (XCS-FEM-DSG3) for free vibration analysis

M. H. NGUYEN-THOI,L. Le-ANH,V. Ho-HUU,H. Dang-TRUNG,T. NGUYEN-THOI

Journal Article

The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Journal Article

Therapeutic potential of stem cell in liver regeneration

Jinzheng LI, Min LI, Bolin NIU, Jianping GONG

Journal Article

Stem cell niches and endogenous electric fields in tissue repair

Li LI, Jianxin JIANG

Journal Article

Transcriptomics and proteomics in stem cell research

Hai Wang,Qian Zhang,Xiangdong Fang

Journal Article

Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation

Xiaodong Mo, Xiaojun Huang

Journal Article

Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

Journal Article

In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Journal Article

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Journal Article

Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity

Chuanfeng Wu, Cynthia E. Dunbar

Journal Article

The stem cell and tissue engineering research in Chinese ophthalmology

GE Jian, LIU Jingbo

Journal Article